Fig. 6: Stably expressed RIP1 directly binds β-catenin and disrupts the β-catenin―β-TrCP complex. | Cancer Gene Therapy

Fig. 6: Stably expressed RIP1 directly binds β-catenin and disrupts the β-catenin―β-TrCP complex.

From: A novel RIP1-mediated canonical WNT signaling pathway that promotes colorectal cancer metastasis via β -catenin stabilization-induced EMT

Fig. 6

A IP analyses were performed with HCT116 and DLD-1 cells transiently transfected with Flag-Mock (pcDNA3.1) or Flag-RIP1 plasmids. B IP analyses were performed with HCT116 and DLD-1 cells transiently transfected with mock control (Con) siRNA or RIP1 (siRIP1). C Proposed model for the role of RIP1 in CRC metastasis.

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