Table 1 Characteristics of circRNA researchs in thyroid cancer.
From: Emerging roles of circular RNAs in regulating the hallmarks of thyroid cancer
Characteristics | Item | Number |
|---|---|---|
Research articles | 100 | |
Pathology | PTC | 85 |
PDTC/ATC | 2 | |
Unclear | 13 | |
Relative exp by III-IV/I-II stage | Higher | 38 |
lower | 4 | |
Unclear | 58 | |
CircRNA | 71 | |
Expression | ||
Up-regulated | 66 | |
Down-regulated | 5 | |
Type | ||
EciRNA | 66 | |
CiRNA | 4 | |
ElciENA | 1 | |
Antisense circRNA | 0 | |
Intergenic circRNA | 0 | |
Mechanisms | ||
Sponge miRNA | 67 | |
RNA-binding proteins | 1 | |
Unclear | 3 | |
Target gene | 66 | |
Signal pathway | ||
PI3K/AKT | 9 | |
MAPK | 6 | |
Wnt/β-catenin | 4 | |
mTOR | 2 | |
AMPK | 2 | |
Hippo | 1 | |
Notch | 1 | |
Hallmarks | ||
Sustaining proliferative signaling | 70 | |
Evading growth suppressors | 46 | |
Avoiding immune destruction | 0 | |
Enabling replicative immortality | 0 | |
Tumor-promoting inflammation | 0 | |
Activating invasion and metastasis | 63 | |
Inducing angiogenesis | 7 | |
Genome instability andmutation | 0 | |
Resisting cell death | 18 | |
Deregulating cellular energetics | 9 | |
Unlocking phenotypic plasticity | 4 | |
Non-mutational epigenetic reprogramming | 4 | |
Polymorphic microbiomes | 0 | |
Senescent cells | 0 | |
