Fig. 6: The oncogenic GnaqQ209L mutation enables in vivo growth of Melan-a cells that is accelerated by transgenic expression of Hgf in the tumor microenvironment. | Cancer Gene Therapy

Fig. 6: The oncogenic GnaqQ209L mutation enables in vivo growth of Melan-a cells that is accelerated by transgenic expression of Hgf in the tumor microenvironment.

From: Transactivation of Met signaling by oncogenic Gnaq drives the evolution of melanoma in Hgf-Cdk4 mice

Fig. 6: The oncogenic GnaqQ209L mutation enables in vivo growth of Melan-a cells that is accelerated by transgenic expression of Hgf in the tumor microenvironment.

a Experimental protocol. b Individual tumor growth curves of Hgf-Cdk4 and Cdk4 mice transplanted with Melan-a Gnaqwt or GnaqQ209L cells. c Corresponding Kaplan–Meier survival curves (***p < 0.005, logrank test).

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