Fig. 1: Elevated ROR2 expression in MB correlates with an unfavorable prognosis.
From: miR-124-3p and miR-194-5p regulation of the PI3K/AKT pathway via ROR2 in medulloblastoma progression
A Uniform Manifold Approximation and Projection (UMAP) visualization and marker-based annotation of cells from the human fetal cerebellum colored by cell type (left panel). Plots in the right panel were colored by the normalized expression of cell-type-specific ROR2 in the human fetal cerebellum. B Expression analysis for ROR2 in MB and control groups using the R2 platform. Control cerebellum, Roth et al., 2008 (n = 9, GSE3526); MB Group1, Pfister et al., 2015 (n = 73, GSE49243); MB Group2, Pfister et al., 2017 (n = 223); MB Group 3, Delattre et al., 2012 (n = 57); MB Group 4, Kool et al., 2009 (n = 62, GSE10327). C, D Expression analysis for ROR2 in WNT, SHH, G3, and G4 groups using the R2 platform. Swartling et al., 2021 (n = 1641, GSE124814). E Survival analysis for ROR2 in WNT and SHH subgroup using the R2 platform. Cavalli et al., 2017 (n = 763, GSE85217). F IF analysis of ROR2 in MB subgroups and control tissues. G Western blot analysis of ROR2 protein in MB and control tissues. H qRT-PCR analysis of relative ROR2 mRNA expression from MB and control tissues. I qRT-PCR analysis of relative ROR2 mRNA expression in MB cell lines and NHA (normal human astrocytes). Data are shown as mean ± SEM; *P < 0.05, **P < 0.01, ***P < 0.001.
