Fig. 5: Common treatment methods targeting telomerase and telomerase. | Cancer Gene Therapy

Fig. 5: Common treatment methods targeting telomerase and telomerase.

From: Understanding, diagnosing, and treating pancreatic cancer from the perspective of telomeres and telomerase

Fig. 5: Common treatment methods targeting telomerase and telomerase.The alternative text for this image may have been generated using AI.

A Telomerase vaccines can recognize TERT peptides on the surface of cells with high TERT levels, thereby promoting the killing of CD4 + T and CD8 + T cells. The oncolytic virus can selectively replicate and lyse cells in cells activated by telomerase. B Small molecule inhibitor BIBR1532 can bind to TERT or TER, prevent the binding between TERT and TER, and inhibit the formation of telomerase. C The oligonucleotide inhibitor imetelstat can compete with telomeres and bind to TER, thereby preventing the binding between telomeres and telomerase. D CDDO Me can weaken hTERT mRNA, basal hTERT, phosphorylated hTERT, and methylation of hTERT promoter, thereby reducing telomerase activity. E G-quadruplex stabilizers can stabilize the G-quadruplex structure of telomeres, prevent DNA helicase from degrading them, and block the telomere elongation process.

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