Fig. 1: The proteomic profiles of AML samples are metabolically impacted by the interactions with BMSC.
From: Proteomic profiling reveals ACSS2 facilitating metabolic support in acute myeloid leukemia
A A schematic diagram depicts how AML protein extracts were created from 14 primary AML cultured overnight in the presence and absence of HS-5 stroma cells, referred to as AML Mono and AML Cocu, respectively. Both AML Mono (n = 14) and AML Cocu (n = 14) were collected and protein lysates were processed for LC-MS/MS to detect proteins involved in signaling pathways stimulated by stroma. B A volcano plot depicts the differential protein expression in AML Cocu with a ≥1.5 fold change relative to AML Mono. Upregulated, downregulated, and proteins below the cutoff of 1.5 fold change are displayed in red, blue, and gray, respectively. C A bar plot depicts top biological pathways that are activated in primary leukemic cells in response to stroma interaction (Supplementary Dataset 1).
