Table 2 Significantly enriched biological pathways of top differentially phosphorylated phosphosites determined by Cytoscape ClueGo with Reactome, KEGG, and WikiPathways as ontology sources of stroma-dependent protection of leukemia cells.
From: Proteomic profiling reveals ACSS2 facilitating metabolic support in acute myeloid leukemia
GO Term | Ontology Source | Bonferroni P-Value | % Associated Genes | Nr. Genes | Genes in cluster |
|---|---|---|---|---|---|
PKB-mediated events | REACTOME | 0.01 | 9.72 | 7 | EIF4B, IRS2, RPS6, TSC2, EIF4EBP1, EIF4G1, RPTOR |
PI3K Cascade | REACTOME | 0.01 | 9.72 | 7 | EIF4B, IRS2, RPS6, TSC2, EIF4EBP1, EIF4G1, RPTOR |
mTOR signaling | REACTOME | 0.01 | 9.72 | 7 | EIF4B, IRS2, RPS6, TSC2, EIF4EBP1, EIF4G1, RPTOR |
mTORC1-mediated signaling | REACTOME | 0.01 | 9.72 | 7 | EIF4B, IRS2, RPS6, TSC2, EIF4EBP1, EIF4G1, RPTOR |
Phosphorylation and inactivation of eEF2K by activated S6K1 | REACTOME | 0.01 | 9.72 | 7 | EIF4B, IRS2, RPS6, TSC2, EIF4EBP1, EIF4G1, RPTOR |
Glycolysis | REACTOME | 0.01 | 16.67 | 5 | PGAM1, TPI1, ENO1, GAPDH, PGK1 |
D-glyceraldehyde 3-phosphate + orthophosphate + NAD + < = > 1,3-bisphospho-D-glycerate + NADH + H+ | REACTOME | 0.01 | 16.67 | 5 | PGAM1, TPI1, ENO1, GAPDH, PGK1 |
1,3-bisphospho-D-glycerate + NADH + H + < = > D-glyceraldehyde 3-phosphate + Orthophosphate + NAD+ | REACTOME | 0.01 | 16.67 | 5 | PGAM1, TPI1, ENO1, GAPDH, PGK1 |
Insulin Signaling | WikiPathways | 0.01 | 6.21 | 10 | IRS2, MAP3K2, MAPK1, RRAD, TSC2, CAP1, EIF4EBP1, PRKCB, PRKCQ, TBC1D4 |
EGF/EGFR Signaling Pathway | WikiPathways | 0.01 | 6.10 | 10 | ATXN2, EPN1, ERRFI1, MAP3K2, MAPK1, MEF2D, RIN1, STMN1, EIF4EBP1, PRKCB |
Interferon type I signaling pathways | WikiPathways | 0.01 | 10.91 | 6 | EIF4B, IRS2, RPS6, TYK2, EIF4EBP1, RPTOR |
Brain-Derived Neurotrophic Factor (BDNF) signaling pathway | WikiPathways | 0.01 | 6.25 | 9 | BAD, IRS2, MAP3K2, MAPK1, MARCKS, RPS6, TSC2, EEF2, EIF4EBP1 |
Integrated Breast Cancer Pathway | WikiPathways | 0.02 | 5.84 | 9 | BAD, MAPK1, SMARCA4, TPR, TSC2, CDK7, CHEK1, MYC, PPP4R3A |
AMPK signaling pathway | KEGG | 0.02 | 6.61 | 8 | CAMKK2, IRS2, TSC2, ACACA, EEF2, EIF4EBP1, ELAVL1, RPTOR |
Glycolysis/Gluconeogenesis | KEGG | 0.03 | 8.96 | 6 | ACSS2, PGAM1, TPI1, ENO1, GAPDH, PGK1 |
