Fig. 7: Detected ctDNA dynamically decreased with treatment, while the TCR of tissues and blood fluctuated with the action of the oncolytic virus. | Cancer Gene Therapy

Fig. 7: Detected ctDNA dynamically decreased with treatment, while the TCR of tissues and blood fluctuated with the action of the oncolytic virus.

From: The long-term effectiveness and mechanism of oncolytic virotherapy combined with anti-PD-L1 antibody in colorectal cancer patient

Fig. 7

A Dynamic changes in ctDNA in the responder, showing the mutation frequencies across different genes at baseline (R W0), week 6 (R W6), and week 12 (R W12). B, E Number of ctDNA mutated genes and the corresponding mutation types detected at baseline. C, F Number of ctDNA mutated genes and the corresponding mutation types detected at week 6. D, G Number of ctDNA mutated genes and the corresponding mutation types detected at week 12. H–J Dynamic changes in ctDNA MSI score, ctDNA TMB, and maximum frequency in the responder over the treatment period.

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