Fig. 7: Cav-1 promotes epithelial cell migration by interacting with ITGα3. | Cancer Gene Therapy

Fig. 7: Cav-1 promotes epithelial cell migration by interacting with ITGα3.

From: Caveolin-1 knockout mitigates breast cancer metastasis to the lungs via integrin α3 dysregulation in 4T1-induced syngeneic breast cancer model

Fig. 7: Cav-1 promotes epithelial cell migration by interacting with ITGα3.

A Interaction between Cav-1 and ITGα3, as predicted using the in silico protein interaction ZDOCK server (https://zdock.umassmed.edu/). B Coimmunoprecipitation of Cav-1 and ITGα3 confirmed their physical interactions. C Wound healing assay of Cav-1 and ITGα3 knock down 4T1 cells showed impaired epithelial cell migration after 24 and 48 h of scratch formation. Graph showing wound closure in the different groups at these time points. Statistical analysis was performed using unpaired Student’s t-test *P < 0.05; ***P < 0.001.

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