Fig. 6: SEVs BST2 promoted lymph node metastasis of PTMC in vivo. | Cancer Gene Therapy

Fig. 6: SEVs BST2 promoted lymph node metastasis of PTMC in vivo.

From: Serum small extracellular vesicles-derived BST2 as a biomarker for papillary thyroid microcarcinoma promotes lymph node metastasis

Fig. 6: SEVs BST2 promoted lymph node metastasis of PTMC in vivo.

A Representative gross anatomical image of the lower limb of a nude mouse with footpad tumor (left arrow) and metastatic popliteal lymph node (right arrow). B Images of the popliteal lymph nodes in control-sEVs-BCPAP or BST2-sEVs-BCPAP groups (n = 12). C Statistical comparison of the volume of popliteal lymph nodes in each group (n = 12, **P < 0.01). D Representative images of HE staining and BST2 IHC staining for popliteal lymph nodes in each group with different magnifications. Scale bars: 100 μm for the 10 × magnified images and 50 μm for the 20 × magnified images. E The IHC staining was assessed as the sum of the percentage and intensity scores (*P < 0.05). Error bars represent standard deviations.

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