Fig. 1: Treatment schedule for hamster and mouse experiments.

Hamsters were treated either by two (A) or three (B) subcutaneous (s.c.) injections, followed by either early (day 24) or late (day 42) termination. GGTA1-KO mice (C) were vaccinated against a-gal followed by tumor implantation. When palpable tumor established, mice were treated by two intratumoral (i.t.) injections and termination was performed when tumor size exceeded 1000 mm3, defined as the humane endpoint criterium. Created in BioRender.