Fig. 2: Consensus mimics inhibit growth in PM cell lines.

A A panel of PM cell lines was transfected with microRNA mimics at a final concentration of 5 nM and proliferation was measured after 72 h. Data are mean ± SD (n = 3). B Cells transfected with the indicated microRNA mimics (5 nM) were transferred to 24-well plates and colony forming ability was measured after 7–10 days. A representative of three independent experiments is shown. C To determine the relative potency of the growth inhibitory activity of the mimics, cells were transfected with a microRNA mimics at a final concentration of 0.039 to 10 nM and proliferation was measured 96 h after transfection. Data are mean ± SD of triplicate measurements and are representative of three independent experiments.