Fig. 6: Consensus mimics control tumour growth in vivo.
From: Therapeutic potential of synthetic microRNA mimics based on the miR-15/107 consensus sequence
Xenograft tumours were formed by implantation of 1 × 106 PM (A) or A549 (B) cells in nude mice. Once tumours reached a size of 100 mm3, treatment began. Mice were treated via tail-vein injection 4× per week (arrows) with 1 × 109 EDVs containing the consensus mimic 107.2, control mimic, or saline. Tumour volume was measured on the indicated days. *P < 0.05, **P < 0.01. C Delivery of the consensus mimics to the xenografts was confirmed by the detection of the novel mimic sequences in RNA-seq analysis.
