Fig. 1: Domain architecture of PLK1 showing KD, IDL region and PBD.
From: Structural regulation of PLK1 activity: implications for cell cycle function and drug discovery
The polo-cap is abbreviated as PC and the two polo-boxes are PB1 and PB2. The D-Box and K492 are two sites shown to be involved in PLK1 degradation. Key amino acid residues identified in the kinase domain include the catalytic Lys82 and two sites of regulatory phosphorylation (Ser137 and Thr210). In the PBD, Trp414, Leu490, Lys492, His538 and Lys540 are critical residues for phosphorecognition.
