Fig. 2: Overlay of PBD-targeted ligands, highlighting the convergence of interactions with the cryptic pocket of PLK1. | Cancer Gene Therapy

Fig. 2: Overlay of PBD-targeted ligands, highlighting the convergence of interactions with the cryptic pocket of PLK1.

From: Structural regulation of PLK1 activity: implications for cell cycle function and drug discovery

Fig. 2

Five CP engaging ligands (see also Fig. 3A) position an aromatic ring similarly as shown left. Yellow: 4X9R (imidazolium-containing phosphopeptide macrocycle 3B); cyan: 5NEI (polotyrin); green: 5NMM (Alpha-Bromo-3-Iodotoluene); magenta: 5NN2 (Z228588490); grey: 4LKM (PL-74); Blue: 3P7 FDPPLHSpTA, PBIP1 residues 71–79); orange: 5J19 AAFSS[pT]PK, Pon residues 58–65).

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