Fig. 4: Overlay of ATP competitive inhibitors of PLK1 obtained to date and highlighting the distinct binding modes observed. | Cancer Gene Therapy

Fig. 4: Overlay of ATP competitive inhibitors of PLK1 obtained to date and highlighting the distinct binding modes observed.

From: Structural regulation of PLK1 activity: implications for cell cycle function and drug discovery

Fig. 4

The binding mode of an ATP analogue with carbon atoms highlighted in yellow is shown for reference. Magenta represents BI2536, volasertib and similar ligands; cyan represents onvansertib and similar ligands; green (2OWB) is a 1,5-dihydropyrrolo[3,4-c]pyrazole derivative.

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