Fig. 3: SLC39A4 accelerated the growth of GC cells in xenograft models. | Cancer Gene Therapy

Fig. 3: SLC39A4 accelerated the growth of GC cells in xenograft models.

From: YTHDF1/SLC39A4 signaling axis promotes gastric cancer cell proliferation by suppressing cuproptosis ex vivo and in vitro

Fig. 3: SLC39A4 accelerated the growth of GC cells in xenograft models.The alternative text for this image may have been generated using AI.

A MKN-45 cells were injected subcutaneously into nude mice, and tumor tissues were collected 28 days later. The diagram was generated by BioRender (https://www.biorender.com/). Changes in tumor volume of the mice received SLC39A4-overexpressed cells (B) and SLC39A4-silenced cells (C). Tumor weight of the mice received SLC39A4-overexpressed cells (D) and SLC39A4-silenced cells (E). Images of tumor tissues formed by SLC39A4-overexpressed cells (F) and SLC39A4-silenced cells (G). N = 8. SLC39A4 Solute carrier family 39 member 4, GC gastric cancer, NC-Sh negative control short hairpin RNA sequence, shSLC39A4-KD-2/5 monoclonal 2/5 that was transfected with a short hairpin RNA sequence targeting SLC39A4, EV empty vector, Ov-SLC39A4-9/48 monoclonal 9/48 that was transfected with a SLC39A4 overexpression plasmid. The data is presented as the mean value ±standard deviation, and p < 0.05 was considered statistically significant.

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