Fig. 8: Schematic depicting how G6PD status modulates the expressions of adhesion molecules, E-cadherin, and β-catenin, which play essential roles in regulating embryonic development | Cell Death & Disease

Fig. 8: Schematic depicting how G6PD status modulates the expressions of adhesion molecules, E-cadherin, and β-catenin, which play essential roles in regulating embryonic development

From: Glucose-6-phosphate dehydrogenase is indispensable in embryonic development by modulation of epithelial-mesenchymal transition via the NOX/Smad3/miR-200b axis

Fig. 8

When the G6PD level is downregulated in cells, the cellular function of NOX is impaired, leading to the loss of redox signaling to induce the expressions of Smad3 and miR-200b. In such conditions, the expressions of E-cadherin and β-catenin are decreased, thus influencing the development of the embryo

Back to article page