Fig. 9: Schematic diagram of the proposed cellular mechanisms for the protection of hiPSC-MSCs-derived EVs after renal I/R injury | Cell Death & Disease

Fig. 9: Schematic diagram of the proposed cellular mechanisms for the protection of hiPSC-MSCs-derived EVs after renal I/R injury

From: Extracellular vesicles from human-induced pluripotent stem cell-derived mesenchymal stromal cells (hiPSC-MSCs) protect against renal ischemia/reperfusion injury via delivering specificity protein (SP1) and transcriptional activating of sphingosine kinase 1 and inhibiting necroptosis

Fig. 9: Schematic diagram of the proposed cellular mechanisms for the protection of hiPSC-MSCs-derived EVs after renal I/R injury

Based on our data, we propose that hiPSC-MSCs-EVs alleviate renal I/R injury by delivering SP1 to the target renal cells and resulting in intracellular activation of SK1 expression and generation of S1P, by which inhibits I/R-induced necroptosis

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