Fig. 4: miR-105-mediated TNF-α-induced EMT in a NF-κB-dependent manner in CRC cells | Cell Death & Disease

Fig. 4: miR-105-mediated TNF-α-induced EMT in a NF-κB-dependent manner in CRC cells

From: MicroRNA-105 is involved in TNF-α-related tumor microenvironment enhanced colorectal cancer progression

Fig. 4: miR-105-mediated TNF-α-induced EMT in a NF-κB-dependent manner in CRC cells

a Western blotting analysis detected the expression of NF-κB family members in HCT116 cells after TNF-α treatment for 48 h (a representative set of data was shown, n = 4). b Effects of overexpressed miR-105 on the expression of NF-κB family members were detected by western blotting analysis (a representative set of data was shown, n = 4). c Effects of miR-105 on TNF-α treated expression of NF-κB family members (a representative set of data was shown, n = 4). d Tumor cells were injected into nude mice through the tail vein to evaluate the lung homing potential of cells. Thalidomide (1.5 mg/kg) was intraperitoneally injected everyday to observe the influence of TNF-α inhibitor on miR-105-induced tumor metastasis. The size and number of metastatic lung nodules in individual mice was counted under the microscope. The magnification areas indicated metastatic nodes in the lung under H&E staining (a representative set of data was shown, n = 2). e The influence of TNF-α inhibitor on miR-105-induced tumor metastasis. Bars represent the number of metastatic lung nodules

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