Fig. 3: RNA-seq analysis of FBXL10 deficiency in DLBCL cells | Cell Death & Disease

Fig. 3: RNA-seq analysis of FBXL10 deficiency in DLBCL cells

From: FBXL10 contributes to the development of diffuse large B-cell lymphoma by epigenetically enhancing ERK1/2 signaling pathway

Fig. 3

a Venn diagrams and a heat map of genes that are consistently 1.5-fold upregulated (top) or 2-fold downregulated (bottom) by FBXL10 knockdown. Pathway analysis of upregulated genes is shown on the right. b GSEA of proteasome genes from human FBXL10 knockdown OCI-Ly1 cells compared with control cells. The normalized enrichment score (NES) reflects the degree to which a gene set is upregulated (positive NES) or downregulated (negative NES). Corresponding P values are indicated. c GSEA of genes associated with spliceosome from human FBXL10 knockdown OCI-Ly1 cells compared with control cells. d-e GSEA of BCL6-specific regulated genes in expression data from FBXL10-deficient OCI-Ly1 cell compared with control cells

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