Fig. 4: The BCL6 target genes such as DUSP6 is derepressed by FBXL10 downregulation in DLBCL cells | Cell Death & Disease

Fig. 4: The BCL6 target genes such as DUSP6 is derepressed by FBXL10 downregulation in DLBCL cells

From: FBXL10 contributes to the development of diffuse large B-cell lymphoma by epigenetically enhancing ERK1/2 signaling pathway

Fig. 4

a Workflow analysis to identify potential cotarget genes for BCL6 and FBXL10 in DLBCL. b A heatmap of genes whose promoters containing BCL6-binding sites and regulated by FBXL10 meanwhile. See also Supplementary Table S3. c–d Expression levels of FBXL10 target genes (DUSP6, HSPA8, PRDM10, and PRDX1) in OCI-Ly1 (c) and SU-DHL-16 (d) cells after FBXL10 knockdown. The mRNA levels were analyzed by quantitative RT-PCR. The error bars denote S.E.M., n = 3. *P < 0.05, and **P < 0.01

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