Fig. 8: Sirt6 overexpression ameliorated puncture-induced IDD in vivo | Cell Death & Disease

Fig. 8: Sirt6 overexpression ameliorated puncture-induced IDD in vivo

From: Sirt6 overexpression suppresses senescence and apoptosis of nucleus pulposus cells by inducing autophagy in a model of intervertebral disc degeneration

Fig. 8

a, b T2-weighted MRI and relative Pfirrmann MRI grade scores of a rat tail with a needle-punctured disc at 8 weeks in each group (white arrows); columns represent mean ± SD. Significant differences between the treatment and control groups are indicated as *P < 0.05, ***P < 0.001, n = 5. c HE staining of each group. d, e Immunohistochemical staining of cleaved-caspase3 and LC3-II expression in the disc samples of each group (scale bar: 200 μm)

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