Fig. 3: BRG1 knockdown inhibited cell proliferation, arrested cell cycle in G1 phase and induced cell apoptosis | Cell Death & Disease

Fig. 3: BRG1 knockdown inhibited cell proliferation, arrested cell cycle in G1 phase and induced cell apoptosis

From: Hepatic SMARCA4 predicts HCC recurrence and promotes tumour cell proliferation by regulating SMAD6 expression

Fig. 3: BRG1 knockdown inhibited cell proliferation, arrested cell cycle in G1 phase and induced cell apoptosis

a–c Representative results of CCK-8 assays assessing the effect of the BRG1 gene on the in vitro proliferation of Li-7, SMMC-7721 and Huh-7 cells after lentivirus-mediated knockdown of BRG1. d, e The effect of BRG1 on the growth of Huh-7 cells in xenograft nude mice models (n = 6) as determined by tumour weight. f Statistical analyses of the results of cell cycle analyses. Knockdown of BRG1 arrested the cell cycle in G1/S phase in Li-7, SMMC-7721 and Huh-7 cells. g The effect of BRG1 knockdown on apoptosis of both Li-7 and SMMC-7721 cells; the levels of caspase-3/7 were measured using a Caspase-Glo 3/7 assay. All results are shown as the mean ± SEM. *P < 0.05; ***P < 0.001

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