Table 1 Protective effect of PFT-α on diabetes-induced cardiac dysfunction

From: Inhibition of p53 prevents diabetic cardiomyopathy by preventing early-stage apoptosis and cell senescence, reduced glycolysis, and impaired angiogenesis

 

Ctrl

PFT-α

DM

DM/PFT-α

2W

IVS;d

0.62 ± 0.02

0.62 ± 0.03

0.61 ± 0.02

0.62 ± 0.04

LVID;d

3.75 ± 0.03

3.74 ± 0.05

3.78 ± 0.02

3.78 ± 0.04

LVPW;d

0.82 ± 0.03

0.85 ± 0.06

0.86 ± 0.03

0.86 ± 0.03

IVS;s

1.01 ± 0.05

1.05 ± 0.05

1.02 ± 0.03

1.02 ± 0.02

LVID;s

2.13 ± 0.05

2.06 ± 0.12

2.22 ± 0.13

2.14 ± 0.08

LVPW;s

1.28 ± 0.04

1.30 ± 0.07

1.29 ± 0.05

1.31 ± 0.02

LV Vol;d

59.87 ± 1.05

59.62 ± 1.31

61.19 ± 1.01

61.13 ± 0.88

LV Vol;s

14.98 ± 0.92

13.71 ± 1.52

16.61 ± 1.24

15.11 ± 1.47

% EF

75.87 ± 2.32

77.01 ± 2.24

72.85 ± 2.62

75.29 ± 2.21

% FS

43.62 ± 1.19

44.98 ± 2.07

41.23 ± 1.86

38.57 ± 1.51

LV Mass

90.77 ± 2.37

94.40 ± 4.70

96.74 ± 4.95

96.54 ± 4.46

3M

IVS;d

0.60 ± 0.02

0.61 ± 0.03

0.60 ± 0.02

0.62 ± 0.02

LVID;d

3.70 ± 0.02

3.75 ± 0.02

3.87 ± 0.05*

3.82 ± 0.02*

LVPW;d

0.85 ± 0.03

0.87 ± 0.04

0.80 ± 0.04*

0.86 ± 0.03

IVS;s

1.02 ± 0.02

1.05 ± 0.04

0.97 ± 0.02*

1.03 ± 0.02

LVID;s

2.01 ± 0.07

2.02 ± 0.03

2.65 ± 0.12*

2.32 ± 0.05†

LVPW;s

1.27 ± 0.02

1.30 ± 0.02

1.28 ± 0.03

1.31 ± 0.02

LV Vol;d

57.98 ± 0.78

59.87 ± 1.05

65.22 ± 1.10*

62.69 ± 1.3†

LV Vol;s

13.13 ± 0.90

13.11 ± 0.45

26.75 ± 1.03*

18.79 ± 0.95†

% EF

77.39 ± 1.36

78.10 ± 1.66

60.26 ± 2.43*

70.30 ± 1.83†

% FS

45.35 ± 1.28

45.99 ± 1.63

30.76 ± 1.06*

39.04 ± 1.24†

LV Mass

89.90 ± 2.22

96.25 ± 2.17

98.01 ± 2.42*

100.41 ± 1.87*

6M

IVS;d

0.62 ± 0.02

0.63 ± 0.03

0.57 ± 0.02*

0.63 ± 0.02†

LVID;d

3.77 ± 0.02

3.82 ± 0.06

4.21 ± 0.02*

3.95 ± 0.06†

LVPW;d

0.86 ± 0.03

0.86 ± 0.05

0.79 ± 0.03*

0.90 ± 0.02†

IVS;s

1.03 ± 0.02

1.04 ± 0.04

0.97 ± 0.01*

1.01 ± 0.06

LVID;s

2.13 ± 0.03

2.15 ± 0.10

3.14 ± 0.10*

2.43 ± 0.05†

LVPW;s

1.35 ± 0.03

1.37 ± 0.02

1.25 ± 0.02*

1.31 ± 0.02†

LV Vol;d

60.66 ± 0.87

63.33 ± 2.23

79.05 ± 0.99*

68.03 ± 2.3†

LV Vol;s

14.87 ± 0.62

15.28 ± 1.91

39.10 ± 3.24*

20.74 ± 1.0†

% EF

75.47 ± 1.32

75.93 ± 2.20

50.58 ± 3.49*

69.48 ± 1.83†

% FS

43.55 ± 1.22

44.04 ± 1.95

25.49 ± 2.13*

38.57 ± 1.51†

LV Mass

95.52 ± 1.92

102.06 ± 2.36

105.64 ± 2.84*

108.57 ± 2.17*

  1. Notes: IVS interventricular septum, LVID d left ventricular internal diastolic diameter, LVID s left ventricular internal systolic diameter, LVPW left ventricular posterior wall, EF ejection fraction, FS fractional shortening, LV vol s left ventricular end systolic volume, LV vol d left ventricular end diastolic volume, LV mass left ventricular mass. Data are presented as the mean ± SD (n = 6)
  2. *, p < 0.05 vs. Ctrl group; †, p < 0.05 vs. DM group
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