Fig. 5: miR-4779 inhibits tumor growth in a mouse xenograft models

a–d Intratumoral injection of miR-4779 suppresses tumor growth in mouse xenografts (n = 6). a HCT116 cells were injected into mice with subcutaneously and miR-NC or miR -4779 was injected as a complex with in vivo-jetPEI into tumors at the indicated time points (arrows), and tumor sizes were measured at the indicated intervals and plotted. b Representative images showing the sizes of tumors injected with miR-NC or miR-4779 at 22 days in A. c At 22 days in A, tumors dissected from mice of each group were weighted and plotted. d Tumor tissues were performed western blot analysis using indicated antibodies. e-h miR-4779 inhibits subcutaneous tumor growth in mouse xenografts (n = 5). e HCT116 cells from transfected with miR-NC or miR-4779 were injected into mice subcutaneously and tumor sizes were measured at the indicated intervals and plotted. f Representative images of the tumor-bearing mice and removed tumors. Mice were sacrificed at 22 days in e. g Tumors dissected from mice of each group (in f) were weighed and plotted. h Tumor tissues were performed western blot analysis using indicated antibodies. Error bars represent mean ± SEM. *P < 0.05 and **P < 0.01