Fig. 1: Notch1 expression was increased in GBM, and elevated Notch1 expression was a prognostic indicator of poor survival in patients with classical GBM | Cell Death & Disease

Fig. 1: Notch1 expression was increased in GBM, and elevated Notch1 expression was a prognostic indicator of poor survival in patients with classical GBM

From: Notch1 is a prognostic factor that is distinctly activated in the classical and proneural subtype of glioblastoma and that promotes glioma cell survival via the NF-κB(p65) pathway

Fig. 1

a Notch1 expression was analyzed in GBM tissues and non-tumor brain tissues from the Murat Brain and Sun Brain data sets. NB, non-tumor brain tissue. b, c Notch1 mRNA expression was analyzed in GBM tissues from the TCGA data sets. Kaplan–Meier survival curve analysis indicated that patients with Notch1 overexpression had a significantly shorter overall survival in the classical subtype of GBM. d Pearson correlation analysis between the Notch1 pathway and NF-κB(p65) (RELA) in TCGA and CGGA data sets. e Notch1 and NF-κB(p65) protein expression levels were elevated in primary glioma patient samples as indicated by the Human Protein Atlas database (http://www.proteinatlas.org/). f The levels of Notch1 in GBM tumor tissues and glioma cell lines were detected by western blotting

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