Fig. 2: Notch1 expression was associated with stemness | Cell Death & Disease

Fig. 2: Notch1 expression was associated with stemness

From: Notch1 is a prognostic factor that is distinctly activated in the classical and proneural subtype of glioblastoma and that promotes glioma cell survival via the NF-κB(p65) pathway

Fig. 2

a, d CD133+ U87, LN229, and U251 human glioma cells that formed neurospheres exhibited higher Notch1 activity and higher expression levels of stem cell markers. The scale bar corresponds to 20 µm. b H&E staining and immunohistochemical staining of CD31, Notch1, Nestin, Jagged-1, and CD133 in GBM tissue. The scale bar corresponds to 100 µm. c Hes1 was expressed in tumor cells adjacent to CD31-expressing endothelial cells. Co-expression of Notch1 and Nestin, Notch1, and CD133 showing the corresponding colocalization in the same cells within the GBM tissue. The scale bar corresponds to 50 µm

Back to article page