Fig. 4: Effect of DAPT on NF-κB(p65) expression in glioma cells | Cell Death & Disease

Fig. 4: Effect of DAPT on NF-κB(p65) expression in glioma cells

From: Notch1 is a prognostic factor that is distinctly activated in the classical and proneural subtype of glioblastoma and that promotes glioma cell survival via the NF-κB(p65) pathway

Fig. 4: Effect of DAPT on NF-κB(p65) expression in glioma cellsThe alternative text for this image may have been generated using AI.

a, b DAPT-induced apoptosis of glioma cells in vitro. The percentages of apoptotic cells were significantly increased after DAPT treatment. c Immunofluorescence shows Hes1 and p65 expression in glioma cells after DAPT treatment. The scale bar corresponds to 20 µm. d After DAPT treatment, the Notch1, NICD, Hes1, p65, cylinD1, p21, Bcl-2, pro-caspase-3, cleaved caspase-3, pro-caspase-9 and cleaved caspase-9 expression levels were detected by western blotting. β-Tubulin was used as a loading control. *P < 0.05, **P < 0.01, ***P < 0.001

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