Fig. 3: Targets for modulation of cell death: some points may act as modulators of cell death depending on the kind of activation | Cell Death & Disease

Fig. 3: Targets for modulation of cell death: some points may act as modulators of cell death depending on the kind of activation

From: Cellular death, reactive oxygen species (ROS) and diabetic complications

Fig. 3

Apoptosis induced by TLR activation has been suggested to be downregulated by silencing of TLR4 gene in experimental model or using soluble RAGE and/or specific antibodies against RAGE. Cell death is a source of HMGB-1, an activator of RAGE. TLR TLR-Toll-like receptors, RAGE receptor for advanced glycation end products.

Back to article page