Fig. 2: Survival analysis in relation to Bok gene methylation
From: The BAX/BAK-like protein BOK is a prognostic marker in colorectal cancer
a Methylation analysis was carried out on 38 matched normal and primary tumour samples from the TCGA COAD cohort. Seven of the 14 Bok methylation sites were significantly different in tumour vs normal tissue (Student’s t-test). 0.5 was used as cutoff (line) to group methylation levels, with values >0.5 representing hypermethylation and values <0.5 representing hypomethylation. Only the seven Bok methylation sites significantly different between tumour vs normal tissues are shown. Note that all differentially expressed Bok methylation sites were hypomethylated in both tumour and normal tissues. b Survival analysis in relation to Bok gene methylation sites. The values of the differentially methylated Bok gene methylation site were averaged and used for survival analysis. Log-rank test result showed no significant difference in the relation to OS in n = 293 patients of the TCGA cohort
