Fig. 2: P53 or NGF was candidate gene of miR-675 or let-7a, respectively (*P < 0.05 compared with the control) | Cell Death & Disease

Fig. 2: P53 or NGF was candidate gene of miR-675 or let-7a, respectively (*P < 0.05 compared with the control)

From: Long non-coding RNA and microRNA-675/let-7a mediates the protective effect of melatonin against early brain injury after subarachnoid hemorrhage via targeting TP53 and neural growth factor

Fig. 2

a miR-675 evidently inhibited luciferase activity of wild-type P53 3′UTR but not that of mutant P53 3′UTR in U87 cells. b miR-675 evidently inhibited luciferase activity of wild-type P53 3′UTR but not that of mutant P53 3′UTR in U251 cells. c Luciferase activity of wild-type but not mutant NGF 3′UTR in U87 cells transfected with let-7a mimic was much lower. d Luciferase activity of wild-type but not mutant NGF 3′UTR in U251 cells transfected with let-7a mimic was much lower

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