Fig. 1: Givinostat effect on infarcted heart and cardiac fibrosis.
From: Givinostat reduces adverse cardiac remodeling through regulating fibroblasts activation
a Echocardiographic measurements indicate an amelioration in fractional shortening (FS), left ventricular end diastolic volume (LVEDV), left ventricular end systolic volume (LVESV), left ventricular end diastolic diameter (LVEDD) and wall thickness (WT). Representative M-mode images of control mice (left panel) and after injection with saline (middle panel) or Givinostat (right panel) in AMI mice. b Western blot analysis shows an increased acetylated H3 protein levels in the whole heart tissue after Givinostat administration compared to saline group. c After Givinostat treatment, four sections per mouse were analyzed by Masson’s trichrome staining. Scale bar represent 1 mm. Percentage of fibrotic area: fibrotic area/total area × 100. Quantitative RT-PCR illustrates the Givinostat effect on the expression of fibrosis-related genes (Col1a1, Col1a2 and Col3a1) at different time points. N = 6 mice for time point. Error bars represent ± SEM. Student’s t test, *p < 0.05, **p < 0.01, #p < 0.001
