Table 2 Univariate and multivariate Cox proportional hazards model for overall survival and postoperative cumulative recurrence
Overall survival | Cumulative recurrence | |||||||
|---|---|---|---|---|---|---|---|---|
Univariate | Multivariate | Univariate | Multivariate | |||||
Factors | HR (95% CI) | P-value | HR (95% CI) | P-value | HR (95% CI) | P-value | HR (95% CI) | P-value |
Sex (female vs. male) | 0.507 (0.202−1.271) | 0.147 | − | − | 0.575 (0.174−1.895) | 0.363 | − | − |
Age, years (>50 vs. ≤50) | 0.627 (0.378−1.066) | 0.085 | − | − | 0.616 (0.297−1.278) | 0.193 | − | − |
Tumor differentiation (III/IV vs. I/II) | 2.140 (1.194−3.835) | 0.011 | 1.300 (0.682−2.479) | 0.425 | 2.094 (0.919−4.768) | 0.078 | ||
Tumor encapsulation (absent vs. present) | 0.957 (0.551−1.662) | 0.877 | − | − | 1.295 (0.622−2.695) | 0.489 | − | − |
Tumor size (diameter, cm) (>5 vs. ≤5) | 5.483 (3.002−10.014) | <0.001 | 3.412 (1.733−6.718) | <0.001 | 7.086 (2.778−18.069) | <0.001 | 4.119 (1.491−11.380) | 0.006 |
Tumor number (multiple vs. single) | 1.597 (0.893−2.856) | 0.114 | − | − | 1.126 (0.481−2.639) | 0.784 | − | − |
Vascular invasion (yes vs. no) | 4.915 (2.769−8.724) | <0.001 | 4.554 (2.429−8.536) | <0.001 | 10.266 (3.829−27.522) | <0.001 | 8.706 (2.977−25.458) | <0.001 |
Liver cirrhosis (yes vs. no) | 0.763 (0.452–1.289) | 0.312 | − | − | 0.697 (0.339−1.433) | 0.327 | − | − |
HBsAg (+ vs. −) | 1.083 (0.463−2.534) | 0.853 | − | − | 0.805 (0.280−2.317) | 0.687 | − | − |
Serum AFP, ng/mL (>20 vs. ≤20) | 2.739 (1.425−5.262) | 0.002 | 1.403 (0.649−3.033) | 0.389 | 3.900 (1.340−11.355) | 0.013 | 2.168 (0.656−7.157) | 0.204 |
Serum ALT, U/L (>75 vs. ≤75) | 2.062 (0.926−4.594) | 0.077 | − | − | 1.860 (0.646−5.361) | 0.250 | − | − |
Serum TB, μmol/L (>17 vs. ≤17) | 0.585 (0.311−1.099) | 0.095 | − | − | 0.490 (0.198−1.212) | 0.122 | − | − |
USP4 expression (high vs. low) | 4.076 (2.106−7.887) | <0.001 | 3.099 (1.510−6.357) | 0.002 | 4.802 (1.760−13.099) | 0.002 | 3.354 (1.123−10.031) | 0.030 |
