Fig. 1: MGL-deficient mice exhibit higher tumor incidence in multiple organs.
From: Monoglyceride lipase gene knockout in mice leads to increased incidence of lung adenocarcinoma
a Quantification of grossly visible tumor nodules observed in all organs of mice with different MGL genotypes. Each number represents an individual mouse examined. *P-value <0.05, **P-value <0.001. The statistical powers are 0.743 for 10–15-month group and 0.972 for 16–24-month group. b Left panel shows an image of normal viscera of MGL+/+ mouse without visible tumor. Right panel displays a MGL+/− mouse with multiple tumor nodules (indicated by arrows) in liver, spleen and abdominal tissues. c Photographic images of grossly observed tumors in various organs in MGL-deficient animals; splenomegaly is also shown. The numbers of individual animals are as indicated. Blue arrows indicate the tumor nodules. d Photographic images of normal-sized and enlarged spleens from MGL wild-type and MGL-deficient animals. The weights of corresponding spleens are also indicated
