Fig. 2: Histological examinations of tumors detected in the lungs and other tissues of MGL-deficient animals.
From: Monoglyceride lipase gene knockout in mice leads to increased incidence of lung adenocarcinoma
a Upper panels (a, b, c, d) show photographs of the tumor nodules in various organs of several different MGL-deficient animals. Individual animal number is as indicated. Middle (4×) and lower (40×) panels show photomicrographs of hematoxylin and eosin (H&E)-stained tissue sections of corresponding tumors. b, c MGL-deficient mice show high incidence of lung adenocarcinoma compared to their wild-type littermates. b Lung tissues from a wild-type MGL mouse (a) and three MGL-deficient mice (b, c, d) are shown. Blue arrows indicate visible tumors (top panel, b, c, d) and their corresponding microscopic images in the middle panel (b’, c’, d’ (4×)). Bottom panel shows microscopic images at a higher magnification (40×). Images in a, a’, a” are from a wild-type MGL mouse. c Comparisons of mice with neoplastic changes in the lungs as noted in the wild-type MGL or MGL-deficient mice of the 16–24-month age group. Each number represents an individual mouse. *P-value <0.05. The statistical power is 0.515
