Table 1 Nodules and splenomegaly observed grossly in all mice examined
From: Monoglyceride lipase gene knockout in mice leads to increased incidence of lung adenocarcinoma
MGL status | No. of mice examined | No. and % mice affected | Organs and observed changes | No. of mice with indicated changesa |
|---|---|---|---|---|
+/+ | N = 30 | 3 (10%) | Lung nodules | 1 |
Splenomegaly | 1 | |||
Liver and spleen nodules | 1 | |||
KO/+ | N = 45 | 25 (56%)* | Lung nodules | 11 |
Splenomegaly, some with nodules | 10 | |||
Liver nodules | 4 | |||
Abdominal nodules | 4 | |||
Neck nodules | 3 | |||
Perianal mass | 1 | |||
Subcutaneous mass | 1 | |||
KO/KO | N = 35 | 21 (60%)* | Lung nodules | 9 |
Splenomegaly, some with nodules | 10 | |||
Liver nodules | 3 | |||
Abdominal nodules | 4 | |||
Cervical/vaginal mass | 1 | |||
Oral mass | 1 |
