Table 2 Mutations in pancreatic ductal adenocarcinoma (PDAC) cells

From: Association of cytosolic sialidase Neu2 with plasma membrane enhances Fas-mediated apoptosis by impairing PI3K-Akt/mTOR-mediated pathway in pancreatic cancer cells

Cell Line

K-ras

AKT2 19q

p16 HD

p16 Mut

13q LOH

BRCA2 Mut

17p LOH

p53 Mut

MKK4 HD

MiaPaCa2

12 Cys

—

HD

—

—

—

LOH

248 Trp

—

AsPc1

12 Asp

Ampl.

—

2 bp del.

LOH

—

LOH

1 bp del.

HD

BxPc3

—

Poss. Ampl.

HD

 

LOH

—

LOH

220 Cys

—

Panc1

12 Asp

Ampl.

HD

 

LOH

—

LOH

273 His

—

  1. MIAPaCa2 is derived from primary tumor, having K-RAS activating mutation, p53 inactivating mutation, and p16 homozygous deletion
  2. AsPC1 is derived from ascites having K-RAS activating mutation, p53 inactivating mutation, p16 frame shift mutation, Akt amplification, and MKK4 homozygous deletion
  3. BxPC3 is derived from primary tumor, having Akt amplification, p53 inactivating mutation, and p16 homozygous deletion
  4. PANC1 is derived from primary tumor, having K-RAS activating mutation, p53 inactivating mutation, and p16 homozygous deletion
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