Fig. 7: Combination therapy delays tumour growth in vivo. | Cell Death & Disease

Fig. 7: Combination therapy delays tumour growth in vivo.

From: Combination therapy with proteasome inhibitors and TLR agonists enhances tumour cell death and IL-1β production

Fig. 7

THP-1 cells stimulated with MPL and bortezomib were examined for a IL-1β secretion and b augmentation of cell death via MTS assay. Mice inoculated with THP-1 cells expressing GFP-luc were either treated with MPL + BTZ (n = 4) or vehicle (n = 3), imaged over 8 weeks for development of tumour signal c, and quantified d along with body weight e. **, *** represent P < 0.01, P < 0.001 using either a two-way ANOVA with Bonferroni post-test or the Wilcoxon signed rank test

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