Fig. 2: MLN2238 treatment induces cell cycle arrest and upregulated p21 and p27 expression in HCC cells. | Cell Death & Disease

Fig. 2: MLN2238 treatment induces cell cycle arrest and upregulated p21 and p27 expression in HCC cells.

From: Preclinical evaluation of antitumor activity of the proteasome inhibitor MLN2238 (ixazomib) in hepatocellular carcinoma cells

Fig. 2

a Images representing cell cycle analysis in cells receiving 250 and 500 nM MLN2238 for 24 h. Left panels, flow cytometry was used to analyze the DNA content of cells after staining with propidium iodide. Right panels, summarized data of cell cycle distribution. Data are expressed as the percentage of cells in the G2/M, S and G0/G1 cell cycle phase, and are expressed as the means of three separate experiments. b Western blot analysis of p21 and p27 in HCC cells after treatment with 250 and 500 nM of MLN2238 for 24 h

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