Fig. 2: miR-27b suppresses cell proliferation, colony formation, and promotes chemosensitivity and PTX-induced apoptosis. | Cell Death & Disease

Fig. 2: miR-27b suppresses cell proliferation, colony formation, and promotes chemosensitivity and PTX-induced apoptosis.

From: miR-27b-3p inhibits proliferation and potentially reverses multi-chemoresistance by targeting CBLB/GRB2 in breast cancer cells

Fig. 2

a, b, c BCap37 cells and Bads-200 cells were transfected with miR-27b mimics (miR-27b) or miR-27b inhibitors, respectively. Cell viability assays, colony formation assays were measured. d, e The sensitivity of BCap37 and Bads-200 cells to multiple anticancer drugs were measured. (BCap37 cells: cisplatin 1 μΜ, doxorubicin 100 nM, gemcitabicin 500 nM, fluorouracil 1.2 μΜ. Bads-200 cells: cisplatin 1 μΜ, doxorubicin 10 μΜ, gemcitabicin 1 μΜ, fluorouracil 2 μΜ). f The sensitivity of MCF-7 and MDA-MB-231 cells to PTX were measured. g The apoptotic rate of BCap37 and Bads-200 cells with specific treatments were measured by flow cytometry analysis

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