Fig. 7: Proposed mechanism of EZH2 regulates ACD of VSMCs and AD occurrence. | Cell Death & Disease

Fig. 7: Proposed mechanism of EZH2 regulates ACD of VSMCs and AD occurrence.

From: EZH2 inhibits autophagic cell death of aortic vascular smooth muscle cells to affect aortic dissection

Fig. 7

In the aorta of AD patients, reduced EZH2 expression results in H3K27me2 and H3K27me3 level decrease, which leads to increase expression of ATG5 and ATG7. On the other hand, the MEK–ERK1/2 signaling pathway is activated by decreased EZH2. Enhanced ATG5 and ATG7 expression and MEK–ERK1/2 signaling activation jointly induce excessive autophagosome formation and then result in ACD of VSMCs, which ultimately accelerates AD occurrence

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