Fig. 8: Prognostic value of OPN and β-Catenin for ICC patients. | Cell Death & Disease

Fig. 8: Prognostic value of OPN and β-Catenin for ICC patients.

From: Osteopontin promotes metastasis of intrahepatic cholangiocarcinoma through recruiting MAPK1 and mediating Ser675 phosphorylation of β-Catenin

Fig. 8

a ICC patients with high OPN expression have a shorter OS and higher probability of recurrence compared with low OPN expression patients. b β-Catenin expression levels were correlated with the OS and probabilities of tumor relapse of ICC patients. c Significant differences in OS and probabilities of tumor relapse among three different subgroups based on the combination of OPN and β-Catenin, i.e., group I, low OPN/low β-Catenin; group II, high OPN/low β-Catenin or low OPN/high β-Catenin; and group III, high OPN/high β-Catenin. Different subgroups were analyzed according to the cutoff values of OPN and β-Catenin levels, which were defined as the median value. The patients with low OPN/low β-Catenin had the best clinical outcomes, while the patients in group III showed the shortest OS and highest possibility of tumor relapse

Back to article page