Fig. 7: Effect of l-BMAA-induced PC on survival, paralysis onset, body weight reduction, and motor functions in SOD1 G93A mice. | Cell Death & Disease

Fig. 7: Effect of l-BMAA-induced PC on survival, paralysis onset, body weight reduction, and motor functions in SOD1 G93A mice.

From: Preconditioning, induced by sub-toxic dose of the neurotoxin L-BMAA, delays ALS progression in mice and prevents Na+/Ca2+ exchanger 3 downregulation

Fig. 7: Effect of l-BMAA-induced PC on survival, paralysis onset, body weight reduction, and motor functions in SOD1 G93A mice.The alternative text for this image may have been generated using AI.

Survival curve of SOD1 G93A mice treated with vehicle compared to l-BMAA preconditioned SOD1 G93A mice (Aa, b). Survival is expressed as percentage (Aa) or in days (Ab). Paralysis onset of SOD1 G93A mice treated with vehicle compared to l-BMAA preconditioned SOD1 G93A mice (Ba, b). Paralysis onset is expressed in days after treatment with vehicle or l-BMAA PC (Ba) or as percentage (Bb). Percentage of body weight reduction in SOD1 G93A vehicle compared to SOD1 G93A mice preconditioned with l-BMAA (Bc). Percentage of rotarod onset and time spent on rotarod by SOD1 G93A mice treated with vehicle compared to SOD1 G93A mice preconditioned with l-BMAA (Ca, b). Grip performance of SOD1 G93A mice treated with vehicle compared to SOD1 G93A mice preconditioned with l-BMAA expressed as percentage (Da) or in seconds (Db). Data are expressed as mean ± SEM for A, b; B, b, c; C,b; and D, b. n = 10 for SOD1 G93A mice treated with vehicle, n = 12 for SOD1 G93A mice preconditioned with l-BMAA, *P < 0.05 vs. SOD1 G93A vehicle mice. Kaplan–Meier plot was used for Aa, Ba, Ca, and Da. Student’s t-test was used for Ab, Bb, c, Cb, Db

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