Fig. 3: Apoptosis was decreased via inhibition of p53 translocation after bFGF treatment. | Cell Death & Disease

Fig. 3: Apoptosis was decreased via inhibition of p53 translocation after bFGF treatment.

From: bFGF plays a neuroprotective role by suppressing excessive autophagy and apoptosis after transient global cerebral ischemia in rats

Fig. 3: Apoptosis was decreased via inhibition of p53 translocation after bFGF treatment.

a Immunoblots of cleaved Caspase-3, Bcl-2, and bFGF from total cell lysates of hippocampal tissue harvested 24 h after I/R. β-actin was used as an internal control. b Immunoblots of p53, Puma, and Bax in the cytosolic and mitochondrial fractions of samples harvested 24 h after I/R. β-actin was used as a loading control for cytosolic proteins, and COX IV was used as the loading control for mitochondrial proteins. c–h Densitometric analysis (mean ± SEM, n = 3 animals per group) of the proteins from (a, b) were normalized to the respective loading controls. **P < 0.01 vs. sham + vehicle; #P < 0.05, ##P < 0.01 vs. I/R + vehicle group; $P < 0.05, $$P < 0.01 vs. I/R + bFGF + rapamycin group

Back to article page