Fig. 1: Unravelling a disrupted molecular clockwork in human PC tissues.

a Expression of eight core clock genes in PC and normal pancreatic tissues (NC) in four independent PC cohorts (cohort 1, GSE19650, GSE32676 and GSE16515). Data are presented as the means ± SEM. *P < 0.05 as compared with the NC groups. b Representative immunochemistry analyses of four circadian proteins in PC and NC tissues from cohort 1 patients. Original magnification ×100; zoomed sections ×200. The IHC scores are shown in the bottom. *P < 0.05