Fig. 1: YAP expression was down-regulated in human ulcerative colitis (UC). | Cell Death & Disease

Fig. 1: YAP expression was down-regulated in human ulcerative colitis (UC).

From: YAP triggers the Wnt/β-catenin signalling pathway and promotes enterocyte self-renewal, regeneration and tumorigenesis after DSS-induced injury

Fig. 1

(a) mRNA expression levels in ulcerative colitis and matched normal tissues (n = 15), as determined by real-time PCR. GAPDH mRNA expression was used as the internal control. Data represent the means ± SEMs. **P < 0.01, ****P < 0.0001. (b) Western blot analysis of total YAP protein expression level in UC and corresponding normal tissues (n = 15). N, normal colon; UC, ulcerative colitis. (c) Immunohistochemical staining of total YAP in normal controls (n = 21), inactive UC (n = 30) and active UC (n = 42) tissues (× 400). Data for the scatter diagrams were generated from immunoreactive scores (IRSs). Scale bars = 20 μm. Data represent the means ± SEMs. *P < 0.05, ***P < 0.001, ****P < 0.0001. (d) The Spearmen’s correlation between YAP expression and colitis severity (r = – 0.674, p < 0.0001). (e) The Spearman’s correlation between Ki67 expression and colitis severity (r = – 0.481, p < 0.0001). (f) The Spearman’s correlation between YAP and Ki67 expression in epithelial cells of patients with UC (r = 0.536, P < 0.0001)

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