Fig. 7: A hypothetical working model of the role of GAS5 in bladder cancer apoptosis. | Cell Death & Disease

Fig. 7: A hypothetical working model of the role of GAS5 in bladder cancer apoptosis.

From: Long noncoding RNA GAS5 promotes bladder cancer cells apoptosis through inhibiting EZH2 transcription

Fig. 7

Overexpression of GAS5 effectively increases the binding of E2F4 to EZH2 mRNA promoter, resulting in repression of EZH2 transcription that promotes tumor cell apoptosis. Meanwhile, this study shows that EZH2 negatively regulated miR-101 transcription in BC, and as we known, miR-101 is a repressor of EZH2. Thus, upregulation of GAS5 results in a positive feedback loop between EZH2 and miR-101. Furthermore, Gambogic acid (GA), a promising natural anticancer compound, could induce bladder cancer cell apoptosis though regulating the expression of both GAS5 and miR-101

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