Fig. 5: Knockdown of PVT1 activates caspases and PARP after radiotherapy. | Cell Death & Disease

Fig. 5: Knockdown of PVT1 activates caspases and PARP after radiotherapy.

From: Long non-coding RNA PVT1 predicts poor prognosis and induces radioresistance by regulating DNA repair and cell apoptosis in nasopharyngeal carcinoma

Fig. 5: Knockdown of PVT1 activates caspases and PARP after radiotherapy.The alternative text for this image may have been generated using AI.

NPC cell lines 5-8F and CNE2 were transfected by either scrambled RNA (NC) or siRNA that targeted PVT1 (siPVT1), and irradiated with a dose of 6 Gy X-radiation. The activation of caspase-7, caspase-9, and PARP was detected by western blot analysis. PVT1 knockdown significantly increased the cleavage of caspase-7, caspase-9, and PARP. GAPDH was used as an internal control.

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