Fig. 4: Aberrant expression of let-7c inhibits migration and invasion of cholangiocarcinoma cells in vitro. | Cell Death & Disease

Fig. 4: Aberrant expression of let-7c inhibits migration and invasion of cholangiocarcinoma cells in vitro.

From: Let-7c inhibits cholangiocarcinoma growth but promotes tumor cell invasion and growth at extrahepatic sites

Fig. 4

a Validation of let-7c expression in TFK-1 cells following treatment with mimic. b overexpressed let-7c inhibited invasive capacity of TFK-1 cells. Decreased migration and invasion in TFK-1 cells with upregulated let-7c expression. Numbers of (c) migrating and (d) invading cells. e Wound-healing assay with transfected TFK-1 cells. f The extent of gap closure in wound-healing assay showing. **P < 0.01. BC blank control group; NC negative control group; 7C+ let-7c-upregulated group

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